A Commitment to Cutting-Edge Research

Researchers at St. Luke’s and Roosevelt Hospitals (SLR) are dedicated to conducting innovative studies and applying their knowledge to improve healthcare. We are committed to providing our clinical sponsors with quality data. As a leading research institute, we excel at accelerated study start-up, rapid enrollment of qualified subjects and the accurate execution of research requirements in a timely and cost-effective manner. We also strive to provide a stimulating work environment and a rewarding and respectful research experience for our study participants. Below is a sampling of some of the clinical investigations currently under way in different divisions at SLR.

The Division of Pulmonary, Critical Care and Sleep Medicine is a Clinical Resource Center for alpha-1 antitrypsin deficiency (A1AD), offering research, patient education and treatment services for this genetic disorder. First described in 1963, A1AD is one of the most common inherited conditions affecting Caucasians. The disorder causes the development of early emphysema, especially in those who smoke. In addition, about 10 percent of the people with A1AD will develop liver disease. The condition is inherited through a classic Mendelian autosomal dominant pattern. Full expression of severe A1AD requires inheritance of the abnormal gene from both parents. Researchers in the division are involved in clinical studies that focus on A1AD screening and detection as well as the exploration of the fundamental mechanisms of emphysema formation in this disorder.

Researchers in the Division of Endocrinology, Diabetes and Nutrition have been involved in two important studies: the Diabetes Prevention Program Outcome Study (DPPOS) and the Look AHEAD (Action for Health in Diabetes) Trial. The DPPOS is a follow-up trial to the Diabetes Prevention Program (DPP), a multi-center clinical trial that studied the efficacy of lifestyle intervention or metformin to prevent or delay the development of diabetes in a high-risk population with impaired glucose tolerance. The DPPOS examines whether the short-term benefits of delaying diabetes shown in the DPP would carry over in a long-term study.

Look AHEAD is a multi-center clinical trial that looks at the long-term effects of a lifestyle intervention of diet and exercise on overweight people with Type 2 diabetes, with a particular focus on reducing cardiovascular disease.

The Division of Gastroenterology has an active research component and its professionals collaborate with investigators in various other divisions. Areas of study include the treatment of hepatitis C, the prevention of recurrences of Clostridium difficile infection, the mechanisms and treatment of irritable bowel syndrome and factors that affect the results of colon cancer screening, specifically the presence of colon polyps. Researchers in the division also investigate aspects of HIV infection, such as the effect of HIV on the gastrointestinal tract, metabolic disturbances and changes in body composition.

The Division of Molecular Virology has a strong focus on the biology of HIV-1, the routes by which HIV infection causes disease, particularly in the central nervous system, and in exploring ways to prevent or lessen the effects of the virus in HIV-positive individuals. Recently, investigators have pursued several major research projects related to HIV brain disease as well as the development of a mouse model of HIV infection and disease.